Feb. 19 (Bloomberg) -- Shire Plc climbed the most in more than 10 months in London trading after unexpected royalties and rebates on the Adderall attention deficit pill helped the U.K. drugmaker to beat fourth-quarter profit estimates. Feb. 19 (Bloomberg) -- Shire Plc climbed the most in more than 10 months in London trading after unexpected royalties and rebates on the Adderall attention deficit pill helped the U.K. drugmaker to beat fourth-quarter profit estimates.